What you learn

understand the mechanism of  the leucine-rich repeat kinase 2 (LRRK2) using correlative light and electron microscopy, in situ cryo-electron tomography, and sub-tomogram analysis

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Delmic Cryo-ET Journal Club Series: Using cryo-ET to understand Parkinson's disease

In this journal club we are going to discuss the article that tackled this barrier using correlative light and electron microscopy, in situ cryo-electron tomography, and sub-tomogram analysis. The authors reveal a 14-Å structure of LRRK2 and show its association with microtubules.