--- title: Everything about cryo-EM | cryo-EM white paper description: Learn everything about cryo-EM, cryo-EM history, cryo-EM workflow, the challenges, and the recent advancements in the world of cryo-EM and cryo-ET. --- ![Whitepaper_Everything-Cryo-EM_Header](https://request.delmic.com/hs-fs/hubfs/Website/Landing%20and%20Thank%20you%20Pages%20Thumbnails/Landing%20Page%20Headers%20-%20Cryo%20Solutions/Whitepaper_Everything-Cryo-EM_Header.png?width=1230&name=Whitepaper_Everything-Cryo-EM_Header.png) ###### Whitepaper # Everything about Cryo-EM: Current trends, challenges, and future directions   ##### What will you learn? - The basics of cryo-electron microscopy (cryo-EM), its history, and its significance in structural biology - How cryo-EM works, along with the challenges and current trends in the SPA cryo-EM and cryo-ET workflow - What the future looks like for cryo-EM and cryo-ET in structural biology ![Whitepaper_Everything-Cryo-EM_Text-and-Image](https://request.delmic.com/hs-fs/hubfs/Website/Landing%20and%20Thank%20you%20Pages%20Thumbnails/Landing%20Page%20Headers%20-%20Cryo%20Solutions/Whitepaper_Everything-Cryo-EM_Text-and-Image.png?width=908&height=681&name=Whitepaper_Everything-Cryo-EM_Text-and-Image.png) ##### **Learn everything you need to know about Cryo-EM, its history, challenges and the recent trends in the SPA cryo-EM and cryo-ET workflow** Cryo-electron microscopy (Cryo-EM), along with cryo-electron tomography (Cryo-ET) have revolutionized structural biology by enabling the visualization of biomacromolecules in their near-native states. The development of rapid freezing techniques, direct electron detectors, and computational algorithms has led to the "resolution revolution," significantly advancing the field. In this white paper, we will explore the basics of cryo-EM, its history, and its significance in the world of structural biology. We will also dive deep into the complex workflow of cryo-EM and examine the recent advancements in single-particle cryo-EM and cryo-ET. *Images courtesy of Dr. S. Berkap, Forschungszentrum Jülich, Germany. * ### Get my copy! [![DELMIC](https://request.delmic.com/hubfs/Delmic_Black+Blue(preferred).svg "DELMIC")](https://www.delmic.com?hsLang=en)